Neuron dendrite function11/11/2023 ![]() ![]() The estimated 100 billion neurons in the human brain ( 2) form approximately 100 trillion synapses onto a total of approximately 100,000 miles of dendritic cable. We speculate that the observed scaling of performance deficits with the degree of structural defect is consistent with gradual increases in intellectual disability during continuously advancing structural deficiencies in progressive neurological disorders.ĭendrites are structural ramifications of a neuron specialized for receiving and processing synaptic input ( 1). To our knowledge, our observations provide the first direct evidence that complex dendrite architecture is critically required for fine-tuning and adaptability within robust, evolutionarily constrained behavioral programs that are vital for mating success and survival. However, significant performance deficits in sophisticated motor behaviors, such as flight altitude control and switching between discrete courtship song elements, scale with the degree of dendritic defect. We find that these motoneuron dendrites are unexpectedly dispensable for synaptic targeting, qualitatively normal neuronal activity patterns during behavior, and basic behavioral performance. Here we probe dendritic function by using genetic tools to selectively abolish dendrites in identified Drosophila wing motoneurons without affecting other neuronal properties. However, the precise consequences of dendritic structure defects for neuronal function and behavioral performance remain unknown. Defects in dendritic structure are highly consistent correlates of brain diseases. Dendrites are highly complex 3D structures that define neuronal morphology and connectivity and are the predominant sites for synaptic input.
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